Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
0.040 GeneticVariation disease BEFREE Cutaneous T-cell lymphoma (CTCL) and adult T-cell leukemia/lymphoma (ATL) are rare non-Hodgkin lymphomas commonly expressing C-C chemokine receptor 4 (CCR4). 31840838 2020
Entrez Id: 2660
Gene Symbol: MSTN
MSTN
0.010 Biomarker disease BEFREE Circulating Mstn is related to muscle mass and nutritional status in HD patients, suggesting that it may have a role in the regulation of skeletal muscle and metabolic processes. 31829144 2019
Entrez Id: 2915
Gene Symbol: GRM5
GRM5
0.030 Biomarker disease BEFREE Since then, five different autoantibodies (mGluR5, Hu, NMDAR, SOX, PCA2) have been associated with Hodgkin's disease. 31826140 2019
Entrez Id: 103164619
Gene Symbol: PCAT2
PCAT2
0.020 Biomarker disease BEFREE Since then, five different autoantibodies (mGluR5, Hu, NMDAR, SOX, PCA2) have been associated with Hodgkin's disease. 31826140 2019
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.100 Biomarker disease BEFREE The aim of this study is to evaluate the immunocytochemical (ICC) expression of CD30, CD15, and PAX5 in Hodgkin's cells (HC) and Reed-Sternberg cells (RSC) on smears and cell-blocks (CB) of HL and to compare the performance of each antibody on smears and CB. 31825183 2020
Entrez Id: 4360
Gene Symbol: MRC1
MRC1
0.020 AlteredExpression disease BEFREE High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination. 31825135 2020
Entrez Id: 6778
Gene Symbol: STAT6
STAT6
0.070 Biomarker disease BEFREE We sought to determine the utility of the novel YE361 STAT6 rabbit monoclonal antibody in Hodgkin lymphoma and diagnostically challenging B- and T-cell non-Hodgkin lymphoma entities with Hodgkin-like features. 31822802 2019
Entrez Id: 10419
Gene Symbol: PRMT5
PRMT5
0.010 AlteredExpression disease BEFREE Protein arginine methyltransferase-5 (PRMT5) is overexpressed in aggressive B-cell non-Hodgkin's lymphomas, including mantle cell lymphoma and diffuse large B-cell lymphoma, and supports constitutive expression of CYCLIN D1 and c-MYC. 31822509 2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.060 Biomarker disease BEFREE Inhibition of MDR1 overcomes resistance to brentuximab vedotin in Hodgkin lymphoma. 31811017 2020
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.050 Biomarker disease BEFREE Inhibition of MDR1 overcomes resistance to brentuximab vedotin in Hodgkin lymphoma. 31811017 2020
Entrez Id: 375704
Gene Symbol: ENHO
ENHO
0.020 GeneticVariation disease BEFREE We investigated in hemodialysis (HD) patients whether CASR single nucleotide polymorphisms (SNPs) rs7652589 and rs1801725 have associations with dyslipidemia and show epistatic interactions with SNPs of the energy homeostasis-associated gene (ENHO), retinoid X receptor α gene (RXRA), and liver X receptor α gene (LXRA). 31775661 2019
Entrez Id: 6256
Gene Symbol: RXRA
RXRA
0.020 GeneticVariation disease BEFREE We investigated in hemodialysis (HD) patients whether CASR single nucleotide polymorphisms (SNPs) rs7652589 and rs1801725 have associations with dyslipidemia and show epistatic interactions with SNPs of the energy homeostasis-associated gene (ENHO), retinoid X receptor α gene (RXRA), and liver X receptor α gene (LXRA). 31775661 2019
Entrez Id: 10062
Gene Symbol: NR1H3
NR1H3
0.010 GeneticVariation disease BEFREE We investigated in hemodialysis (HD) patients whether CASR single nucleotide polymorphisms (SNPs) rs7652589 and rs1801725 have associations with dyslipidemia and show epistatic interactions with SNPs of the energy homeostasis-associated gene (ENHO), retinoid X receptor α gene (RXRA), and liver X receptor α gene (LXRA). 31775661 2019
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.100 GeneticVariation disease BEFREE Thirty-five patients diagnosed with HL who underwent <sup>18</sup>F-FDG PET/CT scans before and during chemotherapy were retrospectively enrolled in this investigation. 31761665 2019
Entrez Id: 1435
Gene Symbol: CSF1
CSF1
0.020 Biomarker disease BEFREE During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor 1 (CSF1) region. 31731509 2019
Entrez Id: 285440
Gene Symbol: CYP4V2
CYP4V2
0.010 Biomarker disease BEFREE Proposed rituximab biosimilar BCD-020 versus reference rituximab for treatment of patients with indolent non-Hodgkin lymphomas: an international multicenter randomized trial. 31724191 2020
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
0.100 GeneticVariation disease BEFREE Ruxolitinib has single-agent activity against HL but does not act against PMBCL with or without JAK2 amplification. 31707975 2019
Entrez Id: 6646
Gene Symbol: SOAT1
SOAT1
0.080 AlteredExpression disease BEFREE The upregulated expression of the JAK/STAT pathway promotes tumor growth in Hodgkin lymphoma (HL) and primary mediastinal large B-cell lymphoma (PMBCL). 31707975 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.400 AlteredExpression disease BEFREE Patients respond well to chemotherapy with cure rates of 80-90% and the recent finding of PD-L1 expression, an immune checkpoint, warrants the use of immunotherapy for some patients with recurrent and/or refractory HL. 31699300 2020
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 AlteredExpression disease BEFREE In addition, EBV-positive and -negative HL cases express survival, but not death signals of ER stress at similar levels and EBV-LMP1 transfection increases expression of survival signals in HL cell lines. 31699300 2020
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.100 Biomarker disease BEFREE The neoplastic cells of HL are of B-cell lineage (PAX5+) in virtually all cases. 31699300 2020
Entrez Id: 930
Gene Symbol: CD19
CD19
0.100 Biomarker disease BEFREE These anti-CD19 chimeric antigen receptor-T cells (CAR) proved to be highly effective in the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) and specific histologic subtypes of B-cell non-Hodgkin lymphomas. 31690821 2019
Entrez Id: 2056
Gene Symbol: EPO
EPO
0.100 Biomarker disease BEFREE Iron deficiency is a common etiology of anemia that causes suboptimal response to erythropoietin therapy in hemodialysis (HD) patients. 31679114 2020
Entrez Id: 970
Gene Symbol: CD70
CD70
0.030 GeneticVariation disease BEFREE This patient is one of the five CD70 deficient individuals described to date, and presented hypogammaglobulinemia, EBV associated Hodgkin's lymphoma and susceptibility to other viral infections. 31678777 2019
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.010 Biomarker disease BEFREE Her previous medical history included COPD, recurrent DVT, atrial fibrillation (on warfarin), hypertension, hypothyroidism, and Hodgkin's lymphoma. 31651255 2019